The scheme will total 910,000 sq ft, split between 890,000 sq ft of office space and around 20,000 sq ft retail.
A Grade II-listed building at 19-21 Billiter Street, built in 1865, will be restored and integrated into the proposed scheme.
It is estimated that 390 full-time construction jobs will be created on the site, with approximately 7,000 people expected to work in the building when complete.
The scheme was designed by Make and varies in height between seven and 34 office storeys, with two additional basement levels, roof-level plant and a range of café, restaurant and retail units.
It was granted planning permission in February last year.
