It was Safeway until the early 90's. After that, it was vacant for a few years until reopening as Office Depot. I had already moved to Seattle by the time Office Depot closed, guessing around 2004.
Safeway had 4 locations around dt:
1) 8th street and 11th ave. The original store was much smaller, had cedar siding and occupied the north side of the site. It was expanded to the south by knocking down a few buildings in 1996, one of which had some heritage value
2) Grid site on 4th Ave and 5th St - demolished
3) Elbow Dr and 25th Ave - relatively unchanged for as long as I can remember
4) East Village - can't remember the exact location but I think it was on 7th or 8th Ave. It has been closed since at least the mid 80's