Overall, I think it's an exceptional floor plan. I like how you walk in and it's very open with a sort of panoramic view of the bedrooms, den, and living/dining area.
I don't see any wasted space and it's very well layed out. I particular like how the den is... open, but on an angle out of the way of the main area.
While the second bedroom is far from the washroom, condos are small so it's not far away. (I purchased a 1 bedroom and the washroom is "far" from the bedroom, but overall it works because you also don't want washrooms too close to the dining/living area). This is really no different than a bathroom down the hall. If anything, the only problem is that if there is someone living in the second bedroom the only bath is in the ensuite of the master. No problem if the second bedroom is only for guests. Also this may be the only way that both bedrooms have windows.
Don't see much that you'd be giving up in terms of a good floor plan.