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- Thread starter MetroMan
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evvabeing
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evvabeing
Senior Member
Rob Ford says 'no' the most: Report tracks voting habits of council
http://www.torontosun.com/2015/10/2...e-most-report-tracks-voting-habits-of-council
JGHali
Active Member
My reference suggests that retroperitoneal liposarcomas rarely cause distant metastases (e.g. to lung or liver) but that local recurrence is "relatively common". This could be a second primary bladder tumour, in which case Ford is just unlucky, or it could be an example of local recurrence. I would bet on the latter, though, as it's arguably more likely. Basically he had an aggressive tumour which commonly recurs locally even when "complete" resection is achieved in an initial surgery.
The survival rates that are getting quoted in most media articles reflect all types of pleomorphic liposarcoma, but the prognosis is a good deal worse for retroperitoneal sarcomas. It depends on how well the original resection went, but who really knows what's going on when the likes of Doug Ford are giving us information.
evvabeing
Senior Member
Roy's Square
Active Member
Yaitsme
Active Member
True enough. Harper grew up with these guys which is why he never slammed but always avoided, I've had to do that with a few folks.
I can see
He's being nice if course lol - not like he can say "screw him I hope he gets crabs" lol
Jimmi T
Senior Member
So if it's malignant does he have to go through chemo again?
Jimmi T
Senior Member
It was on the Live Drive. Probably around 4-5.
Videodrome
Senior Member
Exactly! Tory is taking the high road.
Cooper
Senior Member
Local recurrence sounds most plausible to me. He did have a second tumor in his butt, and the bladder doesn't seem that far from the original tumor site, no? Everything seems to be happening in roughly the same area, and in ways that correspond roughly to my understanding of what I've read. If that's the case, I wonder what treatment options are available. Chemo is probably on the table as way of getting to whatever cells may be floating around. But how much chemo — and how strong a course — a person can stand up to in relatively rapid succession?
Re survival stats: Yes. The media (and Rob) is taking a pretty generic view of things. My recollection is that the 50/50 odds an average of survival rates of PLS occurences in various parts of the body. And even then, there doesn't seem to be a whole lot of data kicking around to firm up the numbers. Not surprising though, given that PLS is rare.
BTW, did anyone ever say Rob's tumor was retroperitoneal? Even the statements from the doctors seemed vague on that point.
JGHali
Active Member
It's going to be very individualized to whether it's a new primary or local recurrence and exactly where it is. Maybe more surgery and/or radiation.
I suppose it may not be retroperitoneal, but the multidisciplinary surgical team (including urology and vascular too?) suggests involvement with the ureter and vessels. The bladder is lower in the pelvis. Could still be a second primary.
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Cooper
Senior Member
A "new primary," would be a new cancer, whereas a "second primary" would be the same cancer but in a new location. Is that right?
JGHali
Active Member
Sorry, I should avoid the jargon. A "new primary" is the same as a "second primary", as it describes some other tumour that is unrelated to the first. This is distinguished from a metastasis which is tumour that has spread and been "deposited" somewhere, but which still arise from the original tumour (the "primary").
So, in Ford's case, the original 10-12 cm tumour was the "primary", which also had a local metastasis, that is, a "secondary" tumour "deposit" in his buttock.
This bladder tumour may be an example of "local recurrence" that shares the same histology (that is, cell type and tumour biology) as the original "primary". It might also be a "primary" bladder tumour which would have a completely different histology from pleomorphic liposarcoma; that is, it would have arisen from different types of cells, and would most likely be a "carcinoma" (a malignant neoplasm arising from epithelial, endothelial, or urothelial cells which are not the same as sarcoma).
It's also possible that this bladder tumour is a "secondary" malignancy that can be attributed to Ford's prior chemo and/or radiation. This would be still be a "primary" carcinoma but would be considered a complication of treatment of the original primary sarcoma. To take another example, although it was never revealed definitively, Jack Layton acquired a "second" cancer following treatment for prostate cancer - this was also a "secondary" malignancy.
Anyway, in this case, this bladder tumour could represent any of the following:
1) local recurrence of the original primary tumour that was resected
2) a new "typical" primary bladder carcinoma not related to prior cancer treatment
3) a new "typical" secondary bladder carcinoma related to prior cancer treatment
4) a benign polyp or some other non-malignant neoplasm
5) something else entirely that's difficult to tease out because the Fords are liars
Treatment will depend on what this is and the only way to know is to get tissue, i.e. biopsy.
So, in Ford's case, the original 10-12 cm tumour was the "primary", which also had a local metastasis, that is, a "secondary" tumour "deposit" in his buttock.
This bladder tumour may be an example of "local recurrence" that shares the same histology (that is, cell type and tumour biology) as the original "primary". It might also be a "primary" bladder tumour which would have a completely different histology from pleomorphic liposarcoma; that is, it would have arisen from different types of cells, and would most likely be a "carcinoma" (a malignant neoplasm arising from epithelial, endothelial, or urothelial cells which are not the same as sarcoma).
It's also possible that this bladder tumour is a "secondary" malignancy that can be attributed to Ford's prior chemo and/or radiation. This would be still be a "primary" carcinoma but would be considered a complication of treatment of the original primary sarcoma. To take another example, although it was never revealed definitively, Jack Layton acquired a "second" cancer following treatment for prostate cancer - this was also a "secondary" malignancy.
Anyway, in this case, this bladder tumour could represent any of the following:
1) local recurrence of the original primary tumour that was resected
2) a new "typical" primary bladder carcinoma not related to prior cancer treatment
3) a new "typical" secondary bladder carcinoma related to prior cancer treatment
4) a benign polyp or some other non-malignant neoplasm
5) something else entirely that's difficult to tease out because the Fords are liars
Treatment will depend on what this is and the only way to know is to get tissue, i.e. biopsy.
evvabeing
Senior Member
you can be nice without saying we need him
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