Reecemartin, don't mind the knee-jerk reactions against your comparison. Plenty of Calgarians bristle at any mention of Toronto.
There are useful comparisons AND contrasts to be made between the C-Train and GO Trains, especially as GO upgrades to a "Regional Express Rail" (RER) system. The C-Train is most GO-like in the south, where it runs along an existing rail corridor that weaves through industrial areas and suburban subdivisions. Those corridors pose similar problems and opportunities for TOD for both the C-Train and the GO-Train. Both systems also face infrastructure limits on their frequency that includes congestion within the city centre (at Union Station, for the GO Train, and along 7th Ave for the C-Train), and at-grade road crossings.
As Social Justice mentioned, the C-Train is a bit better connected to major nodes and amenities outside the core (universities, malls, the stadium, etc.), which gives it more potential to become more of a metro than a commuter service. However, the decision to run the C-Train down the centre of the Crowchild in the NW and along 17th Ave in the SW has got to be one of the stupidest decisions made in the history of the system. In this sense, it's a little more like the Spadina-University subway line running down the middle of the Allen Expressway.